Posted on 02 August 2011.
The increase in the success rates of ART over the past few decades has been mainly attributed to improved laboratory conditions and ovarian stimulation optimization, with less attention directed towards strategies for enhancing final oocyte maturation. A recent study, touted to be the first randomized double blind placebo-controlled clinical trial to alter the ovulation trigger to enhance the developmental competence of oocytes in IVF cycles, has reported a statistically significant improvement in fertilization after a follicle stimulating hormone (FSH) bolus administration at the time of human chorionic gonadotropin (hCG) trigger, compared to placebo, in IVF cycles. Read the full story
Posted in ART, Drugs, Endocrinology, Female Infertility, Fertility, Fertility Preservation, Guidelines, ICSI, IVF, IVF Outcome, Infertility, Laboratory, Pregnancy, Technology
Posted on 04 May 2011.
A new retrospective case-control study has reported that oocyte retrieval via transabdominal ultrasound-guided follicular aspiration is safe and effective in IVF patients with substantial ovarian displacement, i.e. in cases where ovaries are inaccessible transvaginally. The study reported that the results were comparable to cycles where the oocytes were obtained by transvaginal aspiration in women with normally located ovaries. Read the full story
Posted in ART, Diagnostics, Endometriosis, Equipments, Guidelines, ICSI, IVF, IVF Outcome, Infertility, Technology
Posted on 07 November 2008.
Several previous studies have tried to elucidate the complex signaling phenomenon underlying the mammalian oocytes activation. Intracellular Ca2+ oscillations triggered by the penetrated spermatozoa have been found to be crucial for both oocyte activation as well as normal embryo development. Now, a collaborative study conducted by US and UK researchers has reported that the abnormal expression of phospholipase Czeta 1 (PLCZ1) sperm protein is linked to the inability of the human sperm to induce Ca2+ oscillations, leading to failure of egg activation and sterility. Read the full story
Posted in ART, Embryology, Genetics, ICSI, IVF, Infertility, Male Infertility