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Study Reports Positive IVF Outcomes with Metformin in Clomiphene Citrate-resistant PCOS Women

October 25, 2009

Polycystic ovary syndrome (PCOS), affecting around 5-10% of all reproductive-aged women, is one of the most common causes of anovulation. The identification of the role of insulin resistance in women with PCOS, who are also commonly resistant to clomiphene citrate (CC), resulted in the use of insulin sensitizers. The use of metformin, an insulin-sensitizing agent, in PCOS patients undergoing IVF or ovulation induction has been extensively researched, but with divergent results. Now, a new study reports that metformin significantly reduces the incidence of ovarian hyperstimulation syndrome (OHSS) and miscarriage, while positively affecting the oocyte and embryo quality in CC-resistant PCOS women undergoing IVF. The results of the randomized controlled study have been published in the Journal of Obstetrics and Gynecology.

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Published by The IVF NEWS.Direct! Team · Filed Under ART, Female Infertility, ICSI, IVF, IVF Outcome, Infertility, Miscarriage, PCOS 

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